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Literature summary for 3.4.22.29 extracted from
- Viral proteinases (1988), Annu. Rev. Biochem., 57, 701-754.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| eukaryotic translation initiation factor 4F p220 subunit + H2O | Enterovirus C | turns off host-cell protein synthesis | ? | - |
? |  |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | enterovirus | turns off host-cell protein synthesis | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | Hepatovirus A | turns off host-cell protein synthesis | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | coxsackievirus | turns off host-cell protein synthesis | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | picornaviridae | turns off host-cell protein synthesis | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | Human rhinovirus sp. | turns off host-cell protein synthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| coxsackievirus | - |
- |
- |
| enterovirus | - |
bovine enterovirus | - |
| Enterovirus C | - |
type 1 (Mahoney strain) | - |
| Hepatovirus A | - |
- |
- |
| Human rhinovirus sp. | - |
- |
- |
| picornaviridae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from infected HeLa cells | Enterovirus C |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| eukaryotic translation initiation factor 4F p220 subunit + H2O | turns off host-cell protein synthesis | Enterovirus C | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | turns off host-cell protein synthesis | enterovirus | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | turns off host-cell protein synthesis | Hepatovirus A | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | turns off host-cell protein synthesis | coxsackievirus | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | turns off host-cell protein synthesis | picornaviridae | ? | - |
? | |
| eukaryotic translation initiation factor 4F p220 subunit + H2O | turns off host-cell protein synthesis | Human rhinovirus sp. | ? | - |
? | |
| additional information | cleavage specificity | Enterovirus C | ? | - |
? | |
| additional information | cleavage specificity | enterovirus | ? | - |
? | |
| additional information | cleavage specificity | Hepatovirus A | ? | - |
? | |
| additional information | cleavage specificity | coxsackievirus | ? | - |
? | |
| additional information | cleavage specificity | picornaviridae | ? | - |
? | |
| additional information | cleavage specificity | Human rhinovirus sp. | ? | - |
? | |
| additional information | the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) | Enterovirus C | ? | - |
? | |
| additional information | the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) | enterovirus | ? | - |
? | |
| additional information | the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) | coxsackievirus | ? | - |
? | |
| additional information | the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) | picornaviridae | ? | - |
? | |
| additional information | the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) | Human rhinovirus sp. | ? | - |
? | |
| additional information | enzyme is active both as structural element of a precursor and as mature protein | Enterovirus C | ? | - |
? | |
| additional information | enzyme is active both as structural element of a precursor and as mature protein | enterovirus | ? | - |
? | |
| additional information | enzyme is active both as structural element of a precursor and as mature protein | Hepatovirus A | ? | - |
? | |
| additional information | enzyme is active both as structural element of a precursor and as mature protein | coxsackievirus | ? | - |
? | |
| additional information | enzyme is active both as structural element of a precursor and as mature protein | picornaviridae | ? | - |
? | |
| additional information | enzyme is active both as structural element of a precursor and as mature protein | Human rhinovirus sp. | ? | - |
? | |
| P1/P2 precursor polypeptide + H2O | from poliovirus | Enterovirus C | poliovirus 1C'D polypeptide + proteinase 2Apro | - |
? | |
| P1/P2 precursor polypeptide + H2O | from poliovirus | Human rhinovirus sp. | poliovirus 1C'D polypeptide + proteinase 2Apro | - |
? | |
| P1/P2 precursor polypeptide + H2O | from rhinovirus, cleaves P1/P2 junction | Enterovirus C | poliovirus 1C'D polypeptide + proteinase 2Apro | - |
? | |
| P1/P2 precursor polypeptide + H2O | from rhinovirus, cleaves P1/P2 junction | Human rhinovirus sp. | poliovirus 1C'D polypeptide + proteinase 2Apro | - |
? | |
| picornavirus polyprotein + H2O | immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly | Enterovirus C | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly | enterovirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly | Hepatovirus A | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly | coxsackievirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly | picornaviridae | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly | Human rhinovirus sp. | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' | Enterovirus C | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' | enterovirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' | Hepatovirus A | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' | coxsackievirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' | picornaviridae | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' | Human rhinovirus sp. | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins | Enterovirus C | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins | enterovirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins | Hepatovirus A | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins | coxsackievirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins | picornaviridae | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins | Human rhinovirus sp. | hydrolyzed picornavirus polyprotein | - |
? | |
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