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Literature summary for 3.4.22.24 extracted from

  • Ruemenapf, T.; Thiel, H.J.
    434. Cathepsin T (2004), Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press, 2nd Ed., 1404.
No PubMed abstract available
Search for more literature for 3.4.22.24

Activating Compound

Activating Compound Comment Organism Structure
DTT activates Rattus norvegicus
EDTA activates Rattus norvegicus
additional information carbon tetrachloride induces the enzyme 7fold in the liver Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
leupeptin
-
 Rattus norvegicus
tosyl-Lys-methylchloride
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Rattus norvegicus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tyrosine aminotransferase + H2O Rattus norvegicus 53 kDa substrate monomer, cleavage at the N-terminus of the protein, interconversion of the 3 different forms of the substrate enzyme without alteration of its enzymatic activity related to the substrate's short half-life in the cell truncated tyrosine aminotransferase + peptide 49 kDa product monomer and 4.5 kDa N-terminal peptide ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme to homogeneity from liver Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney high activity Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-
small intestine
-
 Rattus norvegicus
-
spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
azocasein + H2O degradation Rattus norvegicus ?
-
 ?
Hemoglobin + H2O denaturation Rattus norvegicus ?
-
 ?
tyrosine aminotransferase + H2O 53 kDa substrate monomer, cleavage at the N-terminus of the protein, interconversion of the 3 different forms of the substrate enzyme without alteration of its enzymatic activity related to the substrate's short half-life in the cell Rattus norvegicus truncated tyrosine aminotransferase + peptide 49 kDa product monomer and 4.5 kDa N-terminal peptide ?
tyrosine aminotransferase + H2O 53 kDa substrate monomer, cleavage at the N-terminus of the protein, interconversion of the 3 different forms of the substrate enzyme without alteration of its enzymatic activity Rattus norvegicus truncated tyrosine aminotransferase + peptide 49 kDa product monomer and 4.5 kDa N-terminal peptide ?

Subunits

Subunits Comment Organism
monomer 1 x 35000 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.9
-
 at 0°C Rattus norvegicus