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Literature summary for 3.4.22.16 extracted from

  • Chornaya, V.; Lyannaya, O.
    Some physicochemical properties of cathepsin H from human meningioma (2004), Exp. Oncol., 26, 278-281.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme from meningogioma shows a 3.5fold increased vmax-value compared to normal tissue, and a 1.3fold decrease in KM-value. Molecular weight of tumor enzyme is decreased Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.039
-
benzoyl-DL-Arg-2-naphthylamide pH 6.0, enzyme from meningioma Homo sapiens
0.05
-
benzoyl-DL-Arg-2-naphthylamide pH 6.0, enzyme from normal tissue Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
enzyme from meningioma Homo sapiens
28000
-
enzyme from normal tissue Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain brain tumor and normal brain tissue Homo sapiens
-
meningioma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-DL-Arg-2-naphthylamide + H2O
-
Homo sapiens benzoyl-DL-Arg + 2-naphthylamine
-
?
L-leucyl-2-naphthylamide + H2O
-
Homo sapiens L-leucine + 2-naphthylamine
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Homo sapiens