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Literature summary for 3.4.22.15 extracted from

  • Waniek, P.; Pacheco Costa, J.; Jansen, A.; Costa, J.; Araujo, C.
    Cathepsin L of Triatoma brasiliensis (Reduviidae, Triatominae): Sequence characterization, expression pattern and zymography (2012), J. Insect Physiol., 58, 178-187.
    View publication on PubMed
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
CA-074 i.e. N-(L-3-trans-propylcarbamoyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline, about 25% residual activity at 0.02 mM; i.e. N-(L-3-trans-propylcarbamoyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline, about 75% residual activity at 0.02 mM Triatoma brasiliensis
E-64 i.e. trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane; i.e. trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane Triatoma brasiliensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23400
-
 x * 23400, mature isoform CATL-1, calculated from amino acid sequence Triatoma brasiliensis
23700
-
 x * 23700, mature isoform CATL-2, calculated from amino acid sequence Triatoma brasiliensis
36800
-
 x * 36800, precursor of isoform CATL-1, SDS-PAGE Triatoma brasiliensis
37100
-
 x * 37100, precursor of isoform CATL-2, SDS-PAGE Triatoma brasiliensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Triatoma brasiliensis
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Triatoma brasiliensis E4W4G9 isoform CATL-1
-
Triatoma brasiliensis G9F9V4 isoform CATL-2
-

Source Tissue

Source Tissue Comment Organism Textmining
midgut highly abundant in the posterior midgut region Triatoma brasiliensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Triatoma brasiliensis ?
-
 ?

Subunits

Subunits Comment Organism
? x * 23400, mature isoform CATL-1, calculated from amino acid sequence Triatoma brasiliensis
? x * 23700, mature isoform CATL-2, calculated from amino acid sequence Triatoma brasiliensis
? x * 36800, precursor of isoform CATL-1, SDS-PAGE Triatoma brasiliensis
? x * 37100, precursor of isoform CATL-2, SDS-PAGE Triatoma brasiliensis

Synonyms

Synonyms Comment Organism
cathepsin L-like proteinase
-
 Triatoma brasiliensis
CATL-1 isoform Triatoma brasiliensis
CATL-2 isoform Triatoma brasiliensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
-
 Triatoma brasiliensis

pH Range

pH Minimum pH Maximum Comment Organism
3.5 5.5 more than 50% activity between pH 3.5 and 5.5 Triatoma brasiliensis

Expression

Organism Comment Expression
Triatoma brasiliensis proteolytic activity increases at 3 days after blood feeding and reaches its maximum at 5 days after feeding, declining thereafter up