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Literature summary for 3.4.22.15 extracted from

  • Leto, G.; Sepporta, M.V.; Crescimanno, M.; Flandina, C.; Tumminello, F.M.
    Cathepsin L in metastatic bone disease: therapeutic implications (2010), Biol. Chem., 391, 655-664.
    View publication on PubMed
Search for more literature for 3.4.22.15

Application

Application Comment Organism
medicine cathepsin L is a target in the treatment of patients with metastatic bone disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome the pro-enzyme is normally activated in the acidic environment of lysosomes Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
 1 * 21000 + 1 * 5000, active form Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
E-cadherin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
E-cadherin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
heterodimer 1 * 21000 + 1 * 5000, active form Homo sapiens

Expression

Organism Comment Expression
Homo sapiens upregulation of osteoclast cathepsin L activity and secretion occurs by cytokines promoting bone resorption, c-Src tyrosine kinase, interleukin-1alpha, interleukin-6, and tumor necrosis factor-alpha. Intracellular expression levels of cathepsin L are upregulated in many human tumors. In U-87MG glioblastoma cells, vascular endothelial growth factor upregulates at transcriptional level cathepsin L up

General Information

General Information Comment Organism
physiological function cathepsin L is involved in bone remodeling processes and contributes to facilitate bone metastasis formation Homo sapiens