Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.15 extracted from

  • Fortenberry, Y.M.; Brandal, S.; Bialas, R.C.; Church, F.C.
    Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration (2010), Biochim. Biophys. Acta, 1800, 580-590.
    View publication on PubMed
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
E-64
-
 Homo sapiens
additional information heparin cofactor II and plasminogen activator inhibitor 1 do not inhibit cathepsin L Homo sapiens
Protein C inhibitor inhibits cathepsin L with an inhibition rate (k2) of 30000 0 M-1 s-1 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
 mature cathepsin L, SDS-PAGE Homo sapiens
31000
-
 pro-cathepsin L, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
 ?

General Information

General Information Comment Organism
malfunction inhibition of cathepsin L results in a decrease in tumor cell migration Homo sapiens