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Literature summary for 3.4.22.15 extracted from

  • Yamazaki, Y.; Kamei, Y.; Sugita, S.; Akaike, F.; Kanai, S.; Miura, S.; Hirata, Y.; Troen, B.R.; Kitamura, T.; Nishino, I.; Suganami, T.; Ezaki, O.; Ogawa, Y.
    The cathepsin L gene is a direct target of FOXO1 in skeletal muscle (2010), Biochem. J., 427, 171-178.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
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Mus musculus
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skeletal muscle
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Mus musculus
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Expression

Organism Comment Expression
Mus musculus fasting-induced cathepsin L expression is suppressed in the skeletal muscle of skeletal-muscle specific Foxo1-knockout mice and in the skeletal muscle of DN-FOXO1 mice down
Mus musculus cathepsin L mRNA expression is markedly increased in the skeletal muscle during fasting. The mouse Ctsl promoter is activated by FOXO1 up