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Literature summary for 3.4.22.15 extracted from

  • Zheng, X.; Chu, F.; Chou, P.; Gallati, C.; Dier, U.; Mirkin, B.; Mousa, S.; Rebbaa, A.
    Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: A putative mechanism (2009), Am. J. Physiol. Cell Physiol., 296, C65-C74.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine cathepsin L inhibition not only reverses but also prevents the development of drug resistance to doxorubicin, tamoxifen, imatinib, trichostatin A, and flutamide Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-naphthalenesulfonyl-Ile-Trp-aldehyde cathepsin L inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
topoisomerase-IIalpha + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SAOS-2 cell
-
Homo sapiens
-
SK-N-SH cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
topoisomerase-IIalpha + H2O
-
Homo sapiens ?
-
?