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Literature summary for 3.4.22.15 extracted from

  • Morin, V.; Sanchez, A.; Quinones, K.; Huidobro, J.G.; Iribarren, C.; Bustos, P.; Puchi, M.; Geneviere, A.M.; Imschenetzky, M.
    Cathepsin L inhibitor I blocks mitotic chromosomes decondensation during cleavage cell cycles of sea urchin embryos (2008), J. Cell. Physiol., 216, 790-795.
    View publication on PubMed
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
Z-Phe-Phe-CH2F i.e. inhibitor I, blocks sea urchin embryogenesis. Complete arrest of cell division is obtained when the embryos are incubated with 100 microM of inhibitor I Tetrapygus niger

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Tetrapygus niger enzyme has a role in the progress of the cell cycle during the cleavage divisions of embryonic development. Inhibition of the protease abolishes the chromatin decondensation after mitosis ?
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 ?

Organism

Organism UniProt Comment Textmining
Tetrapygus niger
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Source Tissue

Source Tissue Comment Organism Textmining
blastomere injection of anti-sperm-hisotone protease antibodies results in arrest of cytokinesis, failure of the chromatin to decondense after mitosis, and blocking of BrdU incorporation into DNA Tetrapygus niger
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme has a role in the progress of the cell cycle during the cleavage divisions of embryonic development. Inhibition of the protease abolishes the chromatin decondensation after mitosis Tetrapygus niger ?
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 ?

Synonyms

Synonyms Comment Organism
sperm-histone protease
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 Tetrapygus niger