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Literature summary for 3.4.22.15 extracted from

  • Funkelstein, L.; Toneff, T.; Hwang, S.R.; Reinheckel, T.; Peters, C.; Hook, V.
    Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression (2008), J. Neurochem., 106, 384-391.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in PC-12 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information cathepsin L knock-out mice show major decreases in adrenocorticotropic hormone, beta-endorphin, and alpha-melanocyte stimulating hormone in pituitary, accompanied by increased levels of proopiomelanocortin Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CLIK-148 treatment of AtT-20 cells results in reduced production of adrenocorticotropic hormone and accumulation of proopiomelanocortin Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
vesicular fraction
-
 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
 SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cathepsin L has a prominent role in the production of adrenocorticotropic hormone, beta-endorphin, and alpha-melanocyte stimulating hormone ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus P06797
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell treatment with inhibitor CLIK-148 results in reduced production of adrenocorticotropic hormone and accumulation of proopiomelanocortin Mus musculus
-
brain
-
 Mus musculus
-
pituitary gland colocalization of cathepsin L with beta-endorphin and alpha-melanocyte stimulating hormone in the intermediate pituitary and with adrenocorticotropic hormone in the anterior pituitary. Partial colocalization with lysosomal marker Lamp-1 adrenocorticotropic hormone Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
additional information cathepsin L has a prominent role in the production of adrenocorticotropic hormone, beta-endorphin, and alpha-melanocyte stimulating hormone Mus musculus ?
-
 ?
pro-neuropeptide Y + H2O cathepsin L cleaves pro-neuropeptide Y (1-70) to generate neuropeptide Y-Gly (1-38) and the COOH-terminal peptide fragment (39-70) Mus musculus neuropeptide Y + ?
-
 ?