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Literature summary for 3.4.22.15 extracted from
- Baboon (Papio ursinus) cathepsin L: purification, characterization and comparison with human and sheep cathepsin L (1995), Comp. Biochem. Physiol. B, 112, 429-439.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Benzyloxycarbonyl-Phe-Phe-CHN2 | - |
Papio ursinus |  |
| dithiothreitol | - |
Papio ursinus | |
| iodoacetic acid | - |
Papio ursinus | |
| leupeptin | - |
Papio ursinus | |
| tosyl-Lys-CH2Cl | - |
Papio ursinus | |
| tosyl-Phe-CH2Cl | - |
Papio ursinus | |
| trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | - |
Papio ursinus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14000 | - |
x * 14000 + x * 26000, SDS-PAGE under reducing conditions | Papio ursinus |
| 26000 | - |
x * 14000 + x * 26000, SDS-PAGE under reducing conditions | Papio ursinus |
| 37000 | - |
the enzyme exists in a 37000 Da form and a 26000 Da form, gel filtration | Papio ursinus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Papio ursinus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| in a single-chain form and in a form of proteolytically active complexes with an endogenous cystatin | Papio ursinus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Papio ursinus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Papio ursinus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| azocasein + H2O | - |
Papio ursinus | ? | - |
? | |
| benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Papio ursinus | ? | - |
? | |
| Gelatin + H2O | - |
Papio ursinus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 14000 + x * 26000, SDS-PAGE under reducing conditions | Papio ursinus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
hydrolysis of benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide | Papio ursinus |
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Release 2023.1 (January 2023)
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