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Literature summary for 3.4.22.10 extracted from

  • Meinert Niclasen, L.; Olsen, J.G.; Dagil, R.; Qing, Z.; Sorensen, O.E.; Kragelund, B.B.
    Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of alpha-1 antitrypsin (2011), Biochem. J., 434, 123-132.
    View publication on PubMed
Search for more literature for 3.4.22.10

Inhibitors

Inhibitors Comment Organism Structure
E64 i.e. trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pyogenes incubation of mature SpeB in 20% (v/v) plasma for 24 h at 37°C does not cause degradation of the protein ?
-
 ?
additional information Streptococcus pyogenes Alab49 incubation of mature SpeB in 20% (v/v) plasma for 24 h at 37°C does not cause degradation of the protein ?
-
 ?
additional information Streptococcus pyogenes AP1 incubation of mature SpeB in 20% (v/v) plasma for 24 h at 37°C does not cause degradation of the protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
-
-
-
Streptococcus pyogenes
-
 serotype M1
-
Streptococcus pyogenes Alab49
-
-
-
Streptococcus pyogenes AP1
-
 serotype M1
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap SP column chromatography, and G75 Sephadex gel filtration Streptococcus pyogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information incubation of mature SpeB in 20% (v/v) plasma for 24 h at 37°C does not cause degradation of the protein Streptococcus pyogenes ?
-
 ?
additional information incubation of mature SpeB in 20% (v/v) plasma for 24 h at 37°C does not cause degradation of the protein Streptococcus pyogenes Alab49 ?
-
 ?
additional information incubation of mature SpeB in 20% (v/v) plasma for 24 h at 37°C does not cause degradation of the protein Streptococcus pyogenes AP1 ?
-
 ?

Synonyms

Synonyms Comment Organism
SpeB
-
 Streptococcus pyogenes
streptococcal pyogenic exotoxin B
-
 Streptococcus pyogenes

General Information

General Information Comment Organism
physiological function addition of SpeB to human plasma increases plasma-mediated bacterial killing and prolonged coagulation time through the intrinsic pathway of coagulation. This effect is independent of the enzymatic activity of SpeB and is mediated by a noncovalent medium-affinity binding and modification of alpha-1 antitrypsin Streptococcus pyogenes