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Literature summary for 3.4.22.10 extracted from

  • Ohkuni, H.; Todome, Y.; Watanabe, Y.; Ishikaw, T.; Takahashi, H.; Kannari, Y.; Kato, H.; Uchiyama, T.; Saito, H.; Fischetti, V.A.; Zabriskie, J.B.
    Studies of recombinant streptococcal pyrogenic exotoxin B/cysteine protease (rSPE B/SCP) in the skin of guinea pigs & the release of histamine from cultured mast cells & basophilic leukocytes (2004), Indian J. Med. Res., 119 Suppl, 33-36.
    View publication on PubMed
Search for more literature for 3.4.22.10

Inhibitors

Inhibitors Comment Organism Structure
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E64, inhibits the capillary permeability increasing effect of the enzyme Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pyogenes the enzyme is a virulence factor of Streptococcus pyogenes inducing the release of histamine in mast cells, basophils, and mononuclear cells, and increasing capillary permeability and histamine release in skin of guinea pigs, the recombinant enzyme shows mitogenic activity with human T-cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is a virulence factor of Streptococcus pyogenes inducing the release of histamine in mast cells, basophils, and mononuclear cells, and increasing capillary permeability and histamine release in skin of guinea pigs, the recombinant enzyme shows mitogenic activity with human T-cells Streptococcus pyogenes ?
-
 ?

Synonyms

Synonyms Comment Organism
SPE B/SCP
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 Streptococcus pyogenes
streptococcal pyrogenic exotoxin B/cysteine protease
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 Streptococcus pyogenes