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Literature summary for 3.4.21.B7 extracted from

  • Brown, K.S.; Keogh, M.J.; Tagiuri, N.; Grainge, M.J.; Presanis, J.S.; Ryder, S.D.; Irving, W.L.; Ball, J.K.; Sim, R.B.; Hickling, T.P.
    Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex (2007), Clin. Exp. Immunol., 147, 90-98.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
mannan-binding lectin
-
Homo sapiens

Application

Application Comment Organism
medicine there is an association of higher MBL/MASP-1 complex activity with liver disease and an association with severity of fibrosis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
?
complement component C2 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MASP-1
-
Homo sapiens
MBL-associated serine protease 1
-
Homo sapiens