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Literature summary for 3.4.21.B6 extracted from

  • Chen, M.; Chen, L.M.; Lin, C.Y.; Chai, K.X.
    Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor (2010), Mol. Cell. Biochem., 337, 259-266.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
hepsin hepsin activates prostasin by cleaving in the amino-terminal pro-peptide region of prostasin at Arg44 Homo sapiens
matriptase matriptase activates prostasin by cleaving in the amino-terminal pro-peptide region of prostasin at Arg44 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in FT-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R44A the mutant cannot be activated by cleavage through hepsin or matriptase Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information active prostasin does not cleave the epidermal growth factor receptor extracellular domain directly, purified active prostasin also does not cleave purified epidermal growth factor receptor Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PRSS8
-
Homo sapiens