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Literature summary for 3.4.21.B6 extracted from
- Regulation of prostasin expression and function in the prostate (2004), Prostate, 59, 1-12.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| nerve growth factor | induces prostasin expression | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | promoter DNA methylation partly causes the prostasin down-regualtion in prostate cancer cell lines | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Protease nexin-1 | inhibits prostasin´s serine protease activity, capable of binding to membrane-anchored prostasin | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16651 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| standard method | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| DU-145 cell | - |
Homo sapiens | - |
| LNCaP cell | - |
Homo sapiens | - |
| additional information | PrEC cell | Homo sapiens | - |
| PC-3 cell | - |
Homo sapiens | - |
| prostate cancer cell line | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-t-Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | ? | - |
? |  |
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