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Literature summary for 3.4.21.B6 extracted from
- Prostasin (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press, 2, 1708-1709.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | blood-borne RT-PCR amplification of prostasin transcripts may provide an early diagnosis of disseminated disease in patients with organ-confined carcinoma | Homo sapiens |
| additional information | coexpression with the epithelial sodium channel increases the amiloride-sensitive sodium current | Xenopus laevis |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Rattus norvegicus |
- |
Xenopus laevis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antipain | - |
Homo sapiens |  |
| Aprotinin | - |
Homo sapiens | |
| benzamidine | - |
Homo sapiens | |
| leupeptin | - |
Homo sapiens | |
| prostasin-binding protein | - |
Homo sapiens | |
| prostasin-binding protein | - |
Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Xenopus laevis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 1960fold | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bronchus | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| epithelial cell | - |
Homo sapiens | - |
| kidney | in the proximal and distal tubular cells | Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| oocyte | - |
Xenopus laevis | - |
| ovary cancer cell | enzyme levels significantly higher than those in control cells | Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| prostate cancer cell | downregulation of the enzyme in high-grade prostate cancer as well as in invasive prostate cancer cells | Homo sapiens | - |
| prostate gland | enzyme levels 20fold higher than in other tissues | Homo sapiens | - |
| salivary gland | in mucous cells | Homo sapiens | - |
| seminal vesicle fluid | enzyme levels 20fold higher than in other tissues | Homo sapiens | - |
| urine | of males and females | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Phe-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | D-Phe-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
| D-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | D-Pro-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
| D-Val-Leu-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | D-Val-Leu-Arg + 7-amino-4-methylcoumarin | - |
? | |
| Z-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Z-Gly-Pro-Arg + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| channel-activating protease-1 | - |
Xenopus laevis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Homo sapiens |
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