Literature summary for 3.4.21.B45 extracted from

Gratio, V.; Loriot, C.; Virca, G.D.; Oikonomopoulou, K.; Walker, F.; Diamandis, E.P.; Hollenberg, M.D.; Darmoul, D.
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells (2011), Am. J. Pathol., 179, 2625-2636.

Search for more literature for 3.4.21.B45

Application

Application	Comment	Organism
medicine	KLK14 and its receptor proteinase-activated receptor-2 represent therapeutic targets for colon tumorigenesis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon adenocarcinoma cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-
additional information	KLK14 is absent in normal epithelia	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein-related peptidase 14	-	Homo sapiens
KLK14	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	KLK14 (0.0001 mM) induces increases in intracellular Ca2+ in HT-29 cells. KLK14 induces significant extracellular signal-regulated kinases 1 and 2 phosphorylation and HT-29 cell proliferation, presumably by activating proteinase-activated receptor-2	Homo sapiens

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Release 2023.1 (January 2023)