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Literature summary for 3.4.21.B43 extracted from

  • Hamilton, B.S.; Whittaker, G.R.
    Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12 (2013), J. Biol. Chem., 288, 17399-17407.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B43

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
influenza hemagglutinin precursor + H2O Homo sapiens the enzyme shows a preference for the H1 and H2 subtypes, the amino acids neighboring the arginine cleavage site affect cleavage efficiency mature influenza hemagglutinin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKR0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information determination of enzyme content in nasal wash sample: about 0.000012 mg/ml Homo sapiens
-
respiratory system
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
influenza hemagglutinin precursor + H2O the enzyme shows a preference for the H1 and H2 subtypes, the amino acids neighboring the arginine cleavage site affect cleavage efficiency Homo sapiens mature influenza hemagglutinin + ?
-
 ?
influenza hemagglutinin precursor + H2O the enzyme shows a preference for the H1 and H2 subtypes, essentially no cleavage of the H3 subtype, the amino acids neighboring the arginine cleavage site affect cleavage efficiency Homo sapiens mature influenza hemagglutinin + ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 12
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function cleavage of the influenza hemagglutinin precursor by host proteases, e.g. kallikrein-related peptidase 12, is a critical step in the virus life cycle. Cleavage activation of influenza hemagglutinin enables fusion with the host endosome, allowing for release of the viral genome into the host cel Homo sapiens