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Literature summary for 3.4.21.B41 extracted from

  • Petraki, C.; Youssef, Y.M.; Dubinski, W.; Lichner, Z.; Scorilas, A.; Pasic, M.D.; Komborozos, V.; Khalil, B.; Streutker, C.; Diamandis, E.P.; Yousef, G.M.
    Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer (2012), Tumour Biol., 33, 1209-1214.
    View publication on PubMed
Search for more literature for 3.4.21.B41

Application

Application Comment Organism
diagnostics KLK10 overexpression correlates with poor prognosis in colorectal cancer, being associated with liver metastases, decreased disease-free, and overall survival. Negative correlation between KLK10 expression and tumor grade, indicating that these two parameters. KLK10 expression, assessed by immunohistochemistry, is an independent indicator of poor prognosis. Assessment of KLK10 can be incorporatedto a multi-molecular prognostic model to achieve better and more accurate assessment of disease prognosis are affected by independent mechanisms Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm immunohistochemic expression analysis, overview Homo sapiens 5737
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Organism

Organism UniProt Comment Textmining
Homo sapiens O43240 gene KLK10
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Source Tissue

Source Tissue Comment Organism Textmining
colonic mucosa cell immunohistochemic expression analysis, overview Homo sapiens
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colorectal cancer cell immunohistochemic expression analysis, overview Homo sapiens
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Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 10
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 Homo sapiens
KLK10
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 Homo sapiens
tissue kallikrein-related peptidase 10
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 Homo sapiens

General Information

General Information Comment Organism
metabolism multiple mechanisms account for enzyme KLK10 dysregulation in cancer including hypermethylation, and the frequent inactivation and loss of KLK10 expression is a critical step towards carcinogenesis Homo sapiens