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Literature summary for 3.4.21.B4 extracted from

  • Cooper, D.M.; Pechkovsky, D.V.; Hackett, T.L.; Knight, D.A.; Granville, D.J.
    Granzyme K activates protease-activated receptor-1 (2011), PLoS ONE, 6, e21484.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B4

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast of lung Homo sapiens
-
lung fibroblast fetal Homo sapiens
-

Synonyms

Synonyms Comment Organism
GRK
-
 Homo sapiens
tryptase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function granzyme K induces pro-inflammatory cytokine release (interleukin-6, interleukin-8 and monocyte chemotactic protein-1) through the activation of protease-activated receptor-1, induces activation of both the ERK1/2 and p38 MAP kinase signaling pathways, and significantly increases fibroblast proliferation Homo sapiens