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Literature summary for 3.4.21.B4 extracted from

  • Guo, Y.; Chen, J.; Zhao, T.; Fan, Z.
    Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity (2008), Mol. Immunol., 45, 2225-2235.
    View publication on PubMed
Search for more literature for 3.4.21.B4

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
S214A inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
redox factor-1/apurinic apyrimidinic endonuclease Ape1 + H2O Homo sapiens Ape1 cleavage by Granzyme K facilitates intracellular reactive oxygen species accumulation and enhances granzyme K-induced cell death ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:CD56+ cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
memory T-cell
-
 Homo sapiens
-
natural killer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
redox factor-1/apurinic apyrimidinic endonuclease Ape1 + H2O Ape1 cleavage by Granzyme K facilitates intracellular reactive oxygen species accumulation and enhances granzyme K-induced cell death Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Gzm K
-
 Homo sapiens