Literature summary for 3.4.21.B4 extracted from

Jackson, D.S.; Fraser, S.A.; Ni, L.M.; Kam, C.M.; Winkler, U.; Johnson, D.A.; Froelich, C.J.; Hudig, D.; Powers, J.C.
Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase (1998), J. Med. Chem., 41, 2289-2301.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3,3-diphenylpropanoyl-Pro-(4-AmPhGly)P(OPh)2	potent inhibitor	Homo sapiens
carbobenzoxy-Thr-(4-AmPhGly)P(OPh)2	quite specific but weak inhibitor	Homo sapiens
Z-LysP(OPh)2	best inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Protein + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Protein + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
S01.146	Merops ID	Homo sapiens

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Release 2023.1 (January 2023)