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Literature summary for 3.4.21.B30 extracted from
- The roles of UmuD in regulating mutagenesis (2010), J. Nucleic Acids, 2010, pii: 947680.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | UmuD2 undergoes autodigestion at elevated pH | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | UmuD2 undergoes autodigestion at elevated pH | Escherichia coli | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UmuD2 | - |
Escherichia coli |
| UmuD2 | - |
Escherichia coli |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Escherichia coli | cellular level of UmuD increases approximately 10fold upon SOS induction | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | UmuD is a dynamic protein that regulates mutagenesis. The UmuD gene products, regulated by the SOS response, exist in two principal forms: UmuD2, which prevents mutagenesis, and UmuD2, which facilitates UV-induced mutagenesis. UmuD slows the resumption of DNA replication after UV irradiation. UmuD interacts with DinB and inhibits its mutagenic -1 frameshift activity. UmuD2 interacts with the RecA/ssDNA filament, which stimulates the ability of UmuD to cleave itself | Escherichia coli |
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