Literature summary for 3.4.21.B28 extracted from

Busek, P.; Balaziova, E.; Matrasova, I.; Hilser, M.; Tomas, R.; Syrucek, M.; Zemanova, Z.; Krepela, E.; Belacek, J.; Sedo, A.
Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma (2016), Tumour Biol., 37, 13961-13971 .

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Application

Application	Comment	Organism
medicine	the limited expression of the enzyme in healthy tissues together with its presence in both transformed and stromal cells suggests that it may be a candidate target for specific delivery of therapeutic agents in glioblastoma	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
glioma cell	increased enzyme expression in a subgroup of high-grade gliomas. The enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth	Homo sapiens	-
mesenchymal cell	the enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth	Homo sapiens	-

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Release 2023.1 (January 2023)