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Literature summary for 3.4.21.B28 extracted from

  • Yang, W.; Han, W.; Ye, S.; Liu, D.; Wu, J.; Liu, H.; Li, C.; Chen, H.
    Fibroblast activation protein-alpha promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms (2013), Exp. Mol. Pathol., 95, 105-110.
    View publication on PubMed
Search for more literature for 3.4.21.B28

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12844
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-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast activated stromal fibroblasts Homo sapiens
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HO-8910PM cell
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 Homo sapiens
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ovary cancer cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
FAPalpha
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 Homo sapiens
fibroblast activation protein-alpha
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 Homo sapiens

General Information

General Information Comment Organism
physiological function fibroblast activation protein-alpha promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms, role of the non-enzymatic activities of the enzyme, overview. The enzyme, together with integrin alpha3beta1 and the uPAR signaling complex, mediates cancer cell migration in the HO-8910PM cell line via the small GTPase Rac1. FAP?-mediated upregulation of p-ERK occurs in a time-dependent manner Homo sapiens