Cloned (Comment) | Organism |
---|---|
quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | the enzyme is an integral membrane protein | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q12844 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | FAP-alpha is significantly increased in breast cancer patients with poor outcome and survival | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
additional information | quantitative real-time PCR enzyme expression analysis | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
FAP-alpha | - |
Homo sapiens |
fibroblast activation protein-alpha | - |
Homo sapiens |
seprase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | FAP-alpha is significantly increased in breast cancer patients with poor outcome and survival | Homo sapiens |
additional information | overexpression of FAP-alpha results in a reduction of phosphorylated focal adhesion kinase level in both MCF-7 cells and MDA-MB-231 cells cultured in normal media and serum-free media, while the growth of MDA-MB-231 cells and the adhesion and invasion ability of both MCF-7 cells and MDA-MB-231 cells are not dramatically influenced by FAP-alpha expression | Homo sapiens |
physiological function | in vitro, FAP-alpha promotes proliferation and inhibits migration of breast cancer cells, potentially by regulating the FAK pathway | Homo sapiens |