Cloned (Comment) | Organism |
---|---|
recombinant expression in Escherichia coli TOP10 cells and transfection of SKOV-3 and HO-8910 cells, two poorly differentiated ovarian serous adenocarcinoma cell lines, using a lentivirus expression vector, quantitative real-time PCR enzyme expression analzsis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q12844 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the enzyme is widely expressed in tumor microenvironment. No enzyme expression in wild-type SKOV-3 and HO-8910 cells, two poorly differentiated ovarian serous adenocarcinoma cell lines | Homo sapiens | - |
ovary cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
FAPalpha | - |
Homo sapiens |
fibroblast activation protein alpha | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the post-prolyl peptidase family | Homo sapiens |
physiological function | the enzyme promotes ovarian cancer cell proliferation, drug resistance, invasiveness, and migration in vitro and it significantly facilitates tumor growth in xenograft tumor tissues. The enzyme might directly promote tumor growth and invasiveness in ovarian cancer cells | Homo sapiens |