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Literature summary for 3.4.21.B28 extracted from

  • Yang, L.; Ma, L.; Lai, D.
    Over-expression of fibroblast activation protein alpha increases tumor growth in xenografts of ovarian cancer cells (2013), Acta Biochim. Biophys. Sin. (Shanghai), 45, 928-937.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in Escherichia coli TOP10 cells and transfection of SKOV-3 and HO-8910 cells, two poorly differentiated ovarian serous adenocarcinoma cell lines, using a lentivirus expression vector, quantitative real-time PCR enzyme expression analzsis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12844
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme is widely expressed in tumor microenvironment. No enzyme expression in wild-type SKOV-3 and HO-8910 cells, two poorly differentiated ovarian serous adenocarcinoma cell lines Homo sapiens
-
ovary cancer cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
FAPalpha
-
Homo sapiens
fibroblast activation protein alpha
-
Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme belongs to the post-prolyl peptidase family Homo sapiens
physiological function the enzyme promotes ovarian cancer cell proliferation, drug resistance, invasiveness, and migration in vitro and it significantly facilitates tumor growth in xenograft tumor tissues. The enzyme might directly promote tumor growth and invasiveness in ovarian cancer cells Homo sapiens