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Literature summary for 3.4.21.B28 extracted from

  • Mori, Y.; Kono, K.; Matsumoto, Y.; Fujii, H.; Yamane, T.; Mitsumata, M.; Chen, W.T.
    The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinoma (2004), Oncology, 67, 411-419.
    View publication on PubMed
Search for more literature for 3.4.21.B28

Application

Application Comment Organism
medicine role in the invasive and metastatic progression of gastric carcinoma, tendency towards a worse prognosis in patients whose tumors exhibit high levels of the 170000 Da seprase dimer Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
97000
-
 Western immunoblotting, monomer Homo sapiens
170000
-
 Western immunoblotting, dimer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell weakly located in microvessel endothelial cells Homo sapiens
-
fibroblast
-
 Homo sapiens
-
gastric cancer cell mainly located, seprase-expressing carcinoma tissue more often found in the scirrhous type than in other types of gastric carcinoma Homo sapiens
-
additional information absent in normal tissue Homo sapiens
-
stromal cell weakly located Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O seprase-dimer Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer Western immunoblotting, 76% expression frequency Homo sapiens
monomer Western immunoblotting Homo sapiens

Synonyms

Synonyms Comment Organism
seprase
-
 Homo sapiens
type II transmembrane serine protease
-
 Homo sapiens