Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | proprotein convertase 5/6 (PC5/6) has two splice variants: soluble PC5/6A and membrane-bound PC5/6B | Mus musculus | 16020 | - |
soluble | proprotein convertase 5/6 (PC5/6) has two splice variants: soluble PC5/6A and membrane-bound PC5/6B | Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
osteopontin + H2O | Mus musculus | Pcsk5/PCSK5 is temporally and spatially expressed with Opn/OPN (Spp1/SPP1) in osteoblasts and osteocytes, indicating that osteopontin could be a physiologically relevant substrate for PC5/6 or PC5/6-activated proteases in bone. Cleavage of osteopontin may modify the function of osteopontin in bone and/or modulate other enzymatic cleavages of osteopontin, leading to alterations in the bone phenotype | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q04592 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | expressed during mouse development in many tissues including bone and tooth | Mus musculus | - |
MC3T3-E1 cell | - |
Mus musculus | - |
MLO-Y4 cell | - |
Mus musculus | - |
osteoblast | primary culture | Mus musculus | - |
osteocyte | - |
Mus musculus | - |
tooth | expressed during mouse development in many tissues including bone and tooth | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
osteopontin + H2O | Pcsk5/PCSK5 is temporally and spatially expressed with Opn/OPN (Spp1/SPP1) in osteoblasts and osteocytes, indicating that osteopontin could be a physiologically relevant substrate for PC5/6 or PC5/6-activated proteases in bone. Cleavage of osteopontin may modify the function of osteopontin in bone and/or modulate other enzymatic cleavages of osteopontin, leading to alterations in the bone phenotype | Mus musculus | ? | - |
? | |
osteopontin + H2O | the enzyme (PC5/6A) efficiently and completely cleaves human osteopontin into three distinct fragments migrating at about 50 kDa, about 18 kDa, and 16 kDa, with evidence for the predicted cleavage sites being at 168RSKSKKFR175-/- and 241KQSR244-/-. PC5/6 also partially cleaves mouse osteopontin to release fragments of about 30 kDa and 29 kDa | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC5/6A | proprotein convertase 5/6 (PC5/6) has two splice variants: soluble PC5/6A and membrane-bound PC5/6B | Mus musculus |
PC5/6B | proprotein convertase 5/6 (PC5/6) has two splice variants: soluble PC5/6A and membrane-bound PC5/6B | Mus musculus |
PCSK5 | - |
Mus musculus |
proprotein convertase 5/6 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | PC5/6-knockout mouse embryos show developmental abnormalities, and reduced overall mineralization | Mus musculus |
physiological function | Pcsk5/PCSK5 is temporally and spatially expressed with Opn/OPN (Spp1/SPP1) in osteoblasts and osteocytes, indicating that osteopontin could be a physiologically relevant substrate for PC5/6 or PC5/6-activated proteases in bone. Cleavage of osteopontin may modify the function of osteopontin in bone and/or modulate other enzymatic cleavages of osteopontin, leading to alterations in the bone phenotype | Mus musculus |