Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B21 extracted from

  • Goetting-Minesky, M.P.; Godovikova, V.; Li, J.J.; Seshadrinathan, S.; Timm, J.C.; Kamodia, S.S.; Fenno, J.C.
    Conservation and revised annotation of the Treponema denticola prcB-prcA-prtP locus encoding the dentilisin (CTLP) protease complex (2013), Mol. Oral Microbiol., 28, 181-191.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B21

Cloned(Commentary)

Cloned (Comment) Organism
gene prtP, the enzyme is encoded in the prcB-prcA-prtP operon, DNA and amino acid sequence determination and analysis, sequence comparisons of different Treponema denticola strains, phylogenetic analysis, cloning in Escherichia coli strain JM109, expression of His6-tagged enzyme in Escherichia coli strain Rosetta(DE3)/pLysS Treponema denticola

Organism

Organism UniProt Comment Textmining
Treponema denticola P96091 gene prtP from strain ATCC 35405; gene prtP, the enzyme is encoded in the prcB-prcA-prtP operon
-
Treponema denticola ATCC 35405 P96091 gene prtP from strain ATCC 35405; gene prtP, the enzyme is encoded in the prcB-prcA-prtP operon
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-4-nitroanilide + H2O
-
 Treponema denticola N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + 4-nitroaniline
-
 ?
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-4-nitroanilide + H2O
-
 Treponema denticola ATCC 35405 N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
CTLP
-
 Treponema denticola
dentilisin
-
 Treponema denticola
PrtP
-
 Treponema denticola

General Information

General Information Comment Organism
physiological function the enzyme dentilisin is a surface protease complex that has a significant role in Treponema denticola-host interactions in periodontal disease Treponema denticola