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Literature summary for 3.4.21.B21 extracted from

  • Cogoni, V.; Morgan-Smith, A.; Fenno, J.C.; Jenkinson, H.F.; Dymock, D.
    Treponema denticola chymotrypsin-like proteinase (CTLP) integrates spirochaetes within oral microbial communities (2012), Microbiology, 158, 759-770.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B21

Inhibitors

Inhibitors Comment Organism Structure
PMSF the inhibitor treatment leads to over 95% inactivation of the enzymes proteolytic activity, but has no effect on adherence of Treponema denticola to the biofilm and Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, and Parvimonas micra Treponema denticola

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Treponema denticola 9986
-
membrane an outer membrane protein Treponema denticola 16020
-

Organism

Organism UniProt Comment Textmining
Treponema denticola
-
-
-
Treponema denticola ATCC 35405
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-4-nitroanilide + H2O
-
 Treponema denticola N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + 4-nitroaniline
-
 ?
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-4-nitroanilide + H2O
-
 Treponema denticola ATCC 35405 N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
chymotrypsin-like proteinase
-
 Treponema denticola
CTLP
-
 Treponema denticola

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Treponema denticola

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
 assay at Treponema denticola

General Information

General Information Comment Organism
physiological function the enzyme is involved in biofilm formation and, within a high-molecular-mass complex on the cell surface, mediates adherence of Treponema denticola to other potential periodontal pathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, and Parvimonas micra. The enzyme's protease activity is not required for the interaction, but the enzyme expression is critical for dual-species biofilm formation, overview Treponema denticola