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Literature summary for 3.4.21.B2 extracted from

  • Lu, H.; Hou, Q.; Zhao, T.; Zhang, H.; Zhang, Q.; Wu, L.; Fan, Z.
    Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation (2006), J. Immunol., 177, 1171-1178.
    View publication on PubMed
Search for more literature for 3.4.21.B2

Application

Application Comment Organism
medicine GzmM initiates caspase-dependent apoptosis, induces DNA fragmentation, but not DNA nicking, Pro-Ject protein transfection reagent can efficiently transport GZmM into target cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens
expressed in Pichia pastoris strain X33 Homo sapiens

Protein Variants

Protein Variants Comment Organism
S182A inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by Ni-affinity chromatography Homo sapiens
nickel affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inhibitor of caspase-activated DNase + H2O
-
 Homo sapiens ?
-
 ?
inhibitor of caspase-activated DNase + H2O direct degradation to release the nuclease activity of caspase-activated DNase for damaging DNA Homo sapiens ?
-
 ?
poly(ADP-ribose) polymerase + H2O
-
 Homo sapiens ?
-
 ?
poly(ADP-ribose) polymerase + H2O cleavage to prevent cellular DNA repair and force apoptosis Homo sapiens ?
-
 ?
succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GZmM
-
 Homo sapiens