Application | Comment | Organism |
---|---|---|
medicine | K4 is not only expressed in prostate cancer cells, but also osteoblasts, in bone metastases. Thus, K4 may have proteolytic roles as a potential mediator of cellular interactions between prostate cancer and bone cells. Complex interactions may occur between prostate cancer and bone cells in the metastatic environment. Co-culture models are a crucial tool in evaluating cellular interactions | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of KLK4 in PC-3 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | markedly decreases migratory potential of K4 clones | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
active K4, Western blot analysis | Homo sapiens |
40000 | - |
pro-K4, Western blot analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNCaP cell | KLK4 mRNA and protein is increased following treatment with conditioned media from SaOs-2 cells | Homo sapiens | - |
osteoblast | of prostate cancer bone metastases | Homo sapiens | - |
PC-3 cell | KLK4 mRNA and protein is increased following treatment with conditioned media from SaOs-2 cells | Homo sapiens | - |
prostate cancer cell | of prostate cancer bone metastases | Homo sapiens | - |
SAOS-2 cell | KLK4 mRNA and protein is not significantly changed in SaOs2 cells treated with conditioned media from either PC-3 cells or LNCaP cells. KLK4 mRNA is clearly increased following direct co-culture of SaOs2 cells with either PC-3 orLNCaP cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HK4 | - |
Homo sapiens |
kallikrein 4 | - |
Homo sapiens |
KLK4 | - |
Homo sapiens |