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Literature summary for 3.4.21.B12 extracted from

  • Gao, J.; Collard, R.L.; Bui, L.; Herington, A.C.; Nicol, D.L.; Clements, J.A.
    Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer (2007), Prostate, 67, 348-360.
    View publication on PubMed

Application

Application Comment Organism
medicine K4 is not only expressed in prostate cancer cells, but also osteoblasts, in bone metastases. Thus, K4 may have proteolytic roles as a potential mediator of cellular interactions between prostate cancer and bone cells. Complex interactions may occur between prostate cancer and bone cells in the metastatic environment. Co-culture models are a crucial tool in evaluating cellular interactions Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of KLK4 in PC-3 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin markedly decreases migratory potential of K4 clones Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
active K4, Western blot analysis Homo sapiens
40000
-
pro-K4, Western blot analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell KLK4 mRNA and protein is increased following treatment with conditioned media from SaOs-2 cells Homo sapiens
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osteoblast of prostate cancer bone metastases Homo sapiens
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PC-3 cell KLK4 mRNA and protein is increased following treatment with conditioned media from SaOs-2 cells Homo sapiens
-
prostate cancer cell of prostate cancer bone metastases Homo sapiens
-
SAOS-2 cell KLK4 mRNA and protein is not significantly changed in SaOs2 cells treated with conditioned media from either PC-3 cells or LNCaP cells. KLK4 mRNA is clearly increased following direct co-culture of SaOs2 cells with either PC-3 orLNCaP cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
HK4
-
Homo sapiens
kallikrein 4
-
Homo sapiens
KLK4
-
Homo sapiens