Literature summary for 3.4.21.B12 extracted from

Nelson, P.S.; Gan, L.; Ferguson, C.; Moss, P.; Gelinas, R.; Hood, L.; Wang, K.
Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression (1999), Proc. Natl. Acad. Sci. USA, 96, 3114-3119.

Search for more literature for 3.4.21.B12

Cloned(Commentary)

Cloned (Comment)	Organism
DNA sequence determination and analysis, chromosome mapping and genomic organization	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	enzyme contains an amino-terminal pre-propeptide sequence, indicating a potential secretory function	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
polypeptide + H2O	Homo sapiens	enzyme is involved in degradation of extracellular matrix and activation of prostate specific antigen PSA and other proteases	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y5K2	gene prostase	-

Reaction

Reaction	Comment	Organism	Reaction ID
proteolysis of polypeptides	enzyme is a serine protease	Homo sapiens	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	enzyme shows a prostate-restricted expression	Homo sapiens	-
prostate	restricted expression in hormonally responsive normal and neoplastic epithelial tissue, but not in prostate stromal constituents	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
polypeptide + H2O	-	Homo sapiens	peptides	-	?
polypeptide + H2O	enzyme is involved in degradation of extracellular matrix and activation of prostate specific antigen PSA and other proteases	Homo sapiens	peptides	-	?

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Release 2023.1 (January 2023)