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Literature summary for 3.4.21.B10 extracted from

  • Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N.M.; Craik, C.S.; Schmitt, M.; Bode, W.; Goettig, P.
    Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7 (2008), Biol. Chem., 389, 623-632.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha2-Macroglobulin
-
Homo sapiens
C1-inhibitor
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q92876
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein one glycosylation site Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information marked preference for Arg over Lys at position P1. Ala and Met are slightly more preferred at position P1 residues than Lys. Strong specificity for Arg and Lys at the P2 position. Activation cleavage site: EQNK-LVHG Homo sapiens ?
-
?
peptide + H2O phage-display analysis using optimum hydrolysis conditions reveals a potential cleavage motif for recombinant human KLK6: W(G/T)-A(K)-R(K)-/-(R/K)-A(R/S)-W(G/F). The preferred P1-P19 scissile bond appears to be a dibasic arginine-arginine/arginine-lysine/lysine-arginine doublet Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 6
-
Homo sapiens
KLK6
-
Homo sapiens
neurosin
-
Homo sapiens
protease M
-
Homo sapiens
serine protease 18
-
Homo sapiens
serine protease 9
-
Homo sapiens