Literature summary for 3.4.21.B1 extracted from

Etscheid, M.; Subramaniam, S.; Lochnit, G.; Zabczyk, M.; Undas, A.; Lang, I.M.; Hanschmann, K.M.; Kanse, S.M.
Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP) (2018), Biochim. Biophys. Acta Mol. Basis Dis., 1864, 3397-3406 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14520	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Fibrinogen + H2O	-	Homo sapiens	?	-	?

General Information

General Information	Comment	Organism
physiological function	FSAP alters fibrin clot properties by fibrinogenolysis. Treatment of human fibrinogen with FSAP releases truncated fibrinogen which shows a delayed thrombin-catalyzed polymerization and forms fibrin clots of reduced turbidity. The clots reveal a less coarse fibrin network with thinner fibers and a smaller pore size. FSAP-treated fibrinogen or plasma exhibits a significantly faster tissue plasminogen activator-driven lysis, which correlates exclusively with cleavage of fibrinogen and not with activation of plasminogen activators	Homo sapiens

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Release 2023.1 (January 2023)