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Literature summary for 3.4.21.B1 extracted from

  • Yoshida, A.; Wang, Y.; Bae, I.; Cao, M.J.; Osatomi, K.; Hara, K.
    Molecular cloning and tissue distribution of hyaluronan binding protein 2 (HABP2) in red sea bream Pagrus major (2013), Comp. Biochem. Physiol. B, 165, 271-276.
    View publication on PubMed
Search for more literature for 3.4.21.B1

Cloned(Commentary)

Cloned (Comment) Organism
gene HABP2, from hepatopancreas, DNA and amino acid sequence determination and analysis, phylogenetic analysis Pagrus major

Protein Variants

Protein Variants Comment Organism
additional information fusion of a modified TSG-6 Link module with mutationally inactivated heparin-binding sequence and the Fc portion of human IgG1 (TSG-6-DELTAHep-Fc) Pagrus major

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzyme has a secretory signal sequence at the N-terminus Pagrus major
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-

Organism

Organism UniProt Comment Textmining
Pagrus major S6B5D3 gene HABP2; gene HABP2
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Pagrus major
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heart
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 Pagrus major
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hepatopancreas
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 Pagrus major
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kidney
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 Pagrus major
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additional information analysis of the tissue distribution of enzyme mRNA, the enzyme is synthesized in hepatopancreas and carried to the muscle, kidney, heart and ovary via the bloodstream in the red sea bream Pagrus major
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muscle
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 Pagrus major
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ovary
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 Pagrus major
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Subunits

Subunits Comment Organism
More the enzyme has a secretory signal sequence at the N-terminus, three epidermal growth factor-like domains, a kringle domain, and a trypsin-like serine protease domain Pagrus major

Synonyms

Synonyms Comment Organism
gelatinolytic serine proteinase
-
 Pagrus major
HABP2
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 Pagrus major
hyaluronan binding protein 2
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 Pagrus major

General Information

General Information Comment Organism
evolution the active site residues of a serine proteinase are conserved in the serine protease domain of the enzyme. The enzyme has a similar domain structure and tissue distribution to those of human hyaluronan binding protein 2 (HABP2), putative phylogenetic tree Pagrus major
physiological function the serine protease is possibly involved in the extracellular matrix turnover. It might be involved in the post-mortem fish muscle softening Pagrus major