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Literature summary for 3.4.21.B1 extracted from

  • Muhl, L.; Hersemeyer, K.; Preissner, K.T.; Weimer, T.; Kanse, S.M.
    Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions (2009), FEBS Lett., 583, 1994-1998.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of recombinant FSAP-isoforms in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
G534E the naturally occurring G534E-variant exhibits reduced proteolytic activity Homo sapiens
additional information the DEGF-3 mutant shows diminished binding to and activation by heparin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulation of FSAP activity is dependent on its EGF-3 domain and over-expression of active variants induces cell death ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14520
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pyroglutamylglycyl-L-arginine-p-nitroanilide + H2O
-
Homo sapiens L-pyroglutamylglycyl-L-arginine + p-nitroaniline
-
?
additional information regulation of FSAP activity is dependent on its EGF-3 domain and over-expression of active variants induces cell death Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
factor VII activating protease
-
Homo sapiens
FSAP
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Homo sapiens