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Literature summary for 3.4.21.B1 extracted from
- Factor VII and single-chain plasminogen activator-activating protease: activation and autoactivation of the proenzyme (2001), Eur. J. Biochem., 268, 3789-3796.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heparin | enhances autoactivation | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | inhibits autoactivation and stabilizes the proenzyme | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58000 | 60000 | nonreducing PAGE, proenzyme | Homo sapiens |
| 60000 | - |
gel-filtration, proenzyme | Homo sapiens |
| 64000 | - |
SDS-PAGE, proenzyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Protein + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | only N-terminal portion is glycosylated, 3.5% carbohydrate content represented by N-glucosamine, N-galactosamine, galactose, mannose, glucose and fucose | Homo sapiens |
| proteolytic modification | autoactivation leads to the typical protease two-chain pattern and subsequent degradation products | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 95% purity | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme displays pro-urokinase-activating properties as well as factor VII-activating protease activity | Homo sapiens | ? | - |
? | |
| Protein + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor VII-activating protease | - |
Homo sapiens |
| FSAP | - |
Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | isoelectric focusing, pH gradient 3-7 | - |
4.9 |
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