Literature summary for 3.4.21.95 extracted from

Bhattacharjee, P.; Bhattacharyya, D.
Factor V activator from Daboia russelli russelli venom destabilizes beta-amyloid aggregate, the hallmark of Alzheimer disease (2013), J. Biol. Chem., 288, 30559-30570.

Search for more literature for 3.4.21.95

Application

Application	Comment	Organism
medicine	small peptides derived from factor V activator destabilize the beta-amyloid aggregate. Peptide CTNIF and a mixture of six peptides are most potent in converting the aggregates to the monomeric state and thus, preventing cytotoxicity in SH-SY5Y human neuroblastoma cells. Some of the peptides are stable in blood for 24 h	Daboia russelii

Organism

Organism	UniProt	Comment	Textmining
Daboia russelii	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Daboia russelii

Source Tissue

Source Tissue	Comment	Organism	Textmining
venom	-	Daboia russelii	-

General Information

General Information	Comment	Organism
physiological function	small peptides derived from factor V activator destabilize the beta-amyloid aggregate. Factor V activator-mediated proteolysis is not involved. Peptide CTNIF and a mixture of six peptides are most potent in converting the aggregates to the monomeric state and thus, preventing cytotoxicity in SH-SY5Y human neuroblastoma cells	Daboia russelii

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)