Crystallization (Comment) | Organism |
---|---|
the crystal structure of RVV-V in complex with the FV14 peptide (residues 1533-1546 of human FV) determined at 1.8 A resolution is shown. The structure reveals multiple interactions between RVV-V and the seven residues, Ile1539 (P7)-Arg1545 (P1), of the cleaved substrate. Comparison with substrate-free structures reveals conformational changes of the RVV-V loops upon substrate binding, suggesting that the multiple interactions are mediated by an induced-fit mechanism | Daboia russelii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Daboia russelii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-SRDPDNIAAWYLRS + H2O | synthetic N-acetylated 14-amino acid peptide (FV-14) | Daboia russelii | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Russell's viper venom factor V (FV) activator | - |
Daboia russelii |
RVV-V | - |
Daboia russelii |