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Literature summary for 3.4.21.93 extracted from
- PICK1 is essential for insulin production and the maintenance of glucose homeostasis (2018), Mol. Biol. Cell, 29, 587-596 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic islet | - |
Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | conditional Pick1-knockout mice lacking protein interacting with C-kinase 1, show elevated proinsulin levels in the circulation and in the pancreatic islets, accompanied by a reduction in the proinsulin processing enzyme prohormone convertase 1/3. The deletion of Pick1 triggers the specific elimination of chromogranin B in pancreatic beta cells | Mus musculus |
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Release 2023.1 (January 2023)
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