Literature summary for 3.4.21.93 extracted from

Lankat-Buttgereit, B.; Mueller, S.; Schmidt, H.; Parhofer, K.G.; Gress, T.M.; Goeke, R.
Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line (2008), Biol. Cell, 100, 703-715.

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Activating Compound

Activating Compound	Comment	Organism	Structure
pioglitazone	oral medication used in the treatment of type 2 diabetes, which decreases Pdcd4 levels, activates Akt, increases CgA and Sg II secretion and augments proprotein convertase 1/3 protein in Bon-1 cells. 7fold increase in proprotein convertase 1/3 mRNA in shPdcd4-transfected cells	Homo sapiens

Application

Application	Comment	Organism
drug development	repression of proprotein convertase 1/3 by Pdcd4 may represent a novel mechanism for the function of Pdcd4 as a tumour suppressor	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	proprotein convertase 1/3 expression is reduced in Bon-1 cells overexpressing Pdcd4	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BON-1 cell	neuroendocrine cell line, which shows dramatic increase in proprotein convertase 1/3 protein expression after suppression of Pdcd4	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enhanced proprotein convertase 1/3 levels, leading to improved processing of proinsulin and proglucagon, may contribute to the benefits of pioglitazone therapy	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PC1	-	Homo sapiens
proprotein convertase 1/3	-	Homo sapiens

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Release 2023.1 (January 2023)