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Literature summary for 3.4.21.93 extracted from

  • Mulcahy, L.R.; Vaslet, C.A.; Nillni, E.A.
    Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides (2005), J. Biol. Chem., 280, 39818-39826.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of PC1 in GH4C1 cells, which lack PC1 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus the enzyme is part of the regulated secretory pathway of neuroendocrine cells Rattus norvegicus 5794
-
secretory granule the enzyme is part of the regulated secretory pathway of neuroendocrine cells Rattus norvegicus 30141
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-thyrotropin-releasing hormone + H2O Rattus norvegicus prohormone processing within the regulated secretory pathway of neuroendocrine cells fragments of pro-thyrotropin-releasing hormone 5 TRH peptide and 7 to 9 other peptides ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroendocrine cell
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
pro-TRH-derived peptide production levels in wild-type and recombinant GH4C1 and AtT20 cells, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-thyrotropin-releasing hormone + H2O prohormone processing within the regulated secretory pathway of neuroendocrine cells Rattus norvegicus fragments of pro-thyrotropin-releasing hormone 5 TRH peptide and 7 to 9 other peptides ?
pro-thyrotropin-releasing hormone + H2O activity with wild-type and mutant pro-TRH, expressed in murine AtT20 cells, recognized epitopes and moieties in pro-TRH by PC1, overview Rattus norvegicus fragments of pro-thyrotropin-releasing hormone 5 TRH peptide and 7 to 9 other peptides ?

Synonyms

Synonyms Comment Organism
PC1
-
Rattus norvegicus
prohormone-convertase 1
-
Rattus norvegicus