Cloned (Comment) | Organism |
---|---|
stable expression of PC1 in GH4C1 cells, which lack PC1 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | the enzyme is part of the regulated secretory pathway of neuroendocrine cells | Rattus norvegicus | 5794 | - |
secretory granule | the enzyme is part of the regulated secretory pathway of neuroendocrine cells | Rattus norvegicus | 30141 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-thyrotropin-releasing hormone + H2O | Rattus norvegicus | prohormone processing within the regulated secretory pathway of neuroendocrine cells | fragments of pro-thyrotropin-releasing hormone | 5 TRH peptide and 7 to 9 other peptides | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroendocrine cell | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
pro-TRH-derived peptide production levels in wild-type and recombinant GH4C1 and AtT20 cells, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-thyrotropin-releasing hormone + H2O | prohormone processing within the regulated secretory pathway of neuroendocrine cells | Rattus norvegicus | fragments of pro-thyrotropin-releasing hormone | 5 TRH peptide and 7 to 9 other peptides | ? | |
pro-thyrotropin-releasing hormone + H2O | activity with wild-type and mutant pro-TRH, expressed in murine AtT20 cells, recognized epitopes and moieties in pro-TRH by PC1, overview | Rattus norvegicus | fragments of pro-thyrotropin-releasing hormone | 5 TRH peptide and 7 to 9 other peptides | ? |
Synonyms | Comment | Organism |
---|---|---|
PC1 | - |
Rattus norvegicus |
prohormone-convertase 1 | - |
Rattus norvegicus |