Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Pro-opiomelanocortin + H2O | Mus musculus | the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors | ? | - |
? | |
Pro-opiomelanocortin + H2O | Homo sapiens | the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors | ? | - |
? | |
Proinsulin + H2O | Mus musculus | the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors | ? | - |
? | |
Proinsulin + H2O | Homo sapiens | the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AtT-20 cell | anterior | Mus musculus | - |
pancreatic islet | - |
Mus musculus | - |
pancreatic islet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Pro-opiomelanocortin + H2O | - |
Mus musculus | Adrenocorticotropic hormone + beta-lipotropin + beta endorphin | small amounts of beta-endorphin | ? | |
Pro-opiomelanocortin + H2O | - |
Homo sapiens | Adrenocorticotropic hormone + beta-lipotropin + beta endorphin | small amounts of beta-endorphin | ? | |
Pro-opiomelanocortin + H2O | the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors | Mus musculus | ? | - |
? | |
Pro-opiomelanocortin + H2O | the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors | Homo sapiens | ? | - |
? | |
Proinsulin + H2O | cleaves at both C peptide junctions to release rat insulin I but generates a larger proportion of intermediate cleaved at the B chain-C peptide junction, indicating a preference for this site | Mus musculus | Insulin + ? | - |
? | |
Proinsulin + H2O | cleaves at both C peptide junctions to release rat insulin I but generates a larger proportion of intermediate cleaved at the B chain-C peptide junction, indicating a preference for this site | Homo sapiens | Insulin + ? | - |
? | |
Proinsulin + H2O | the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors | Mus musculus | ? | - |
? | |
Proinsulin + H2O | the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors | Homo sapiens | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
- |
Mus musculus |
5.5 | - |
- |
Homo sapiens |