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Literature summary for 3.4.21.92 extracted from

  • El Bakkouri, M.; Pow, A.; Mulichak, A.; Cheung, K.L.; Artz, J.D.; Amani, M.; Fell, S.; de Koning-Ward, T.F.; Goodman, C.D.; McFadden, G.I.; Ortega, J.; Hui, R.; Houry, W.A.
    The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum (2010), J. Mol. Biol., 404, 456-477.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
the X-ray structure of PfClpP shows the protein as a compacted tetradecamer Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.065
-
Suc-LLVY-4-methylcoumarin-7-amide 30°C, pH 7.0 Plasmodium falciparum
0.065
-
Suc-LLVY-4-methylcoumarin-7-amide succinyl-LLVY-7-amido-4-methylcoumarin Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
apicoplast
-
Plasmodium falciparum 20011
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
Western blot Plasmodium falciparum
43000
-
calculated from cDNA, unprocessed protein Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum O97252 parasite contains four Clp ATPases, one protease subunit ClpP and one inactive protease ClpR
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O
-
Plasmodium falciparum ?
-
?
Suc-AAPF-4-methylcoumarin-7-amide + H2O
-
Plasmodium falciparum ?
-
?
Suc-AFK-4-methylcoumarin-7-amide + H2O
-
Plasmodium falciparum ?
-
?
Suc-IA-4-methylcoumarin-7-amide + H2O
-
Plasmodium falciparum ?
-
?
Suc-IIW-4-methylcoumarin-7-amide + H2O
-
Plasmodium falciparum ?
-
?
Suc-LY-4-methylcoumarin-7-amide + H2O
-
Plasmodium falciparum ?
-
?
succinyl-LLVY-7-amido-4-methylcoumarin + H2O
-
Plasmodium falciparum succinyl-LLVY + 7-amino-4-methylcoumarin
-
?

Subunits

Subunits Comment Organism
heptamer homoheptamer, gel filtration Plasmodium falciparum
tetradecamer crystal structure Plasmodium falciparum

Synonyms

Synonyms Comment Organism
PfClpP
-
Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.000036
-
succinyl-LLVY-7-amido-4-methylcoumarin 30°C, pH 7.0, PfClpP is a very weak peptidase on its own Plasmodium falciparum