Literature summary for 3.4.21.92 extracted from

Cao, J.; Chen, T.; Li, D.; Wong, C.K.; Chen, D.; Xu, W.; Zhang, X.; Lam, C.W.; Yin, Y.
Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice (2008), Microbes Infect., 10, 1536-1542.

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Application

Application	Comment	Organism
medicine	protective efficacy of mucosal immunization with ClpP as a promising pneumococcal protein antigen	Streptococcus pneumoniae TIGR4

Cloned(Commentary)

Cloned (Comment)	Organism
-	Streptococcus pneumoniae TIGR4

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae TIGR4	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Streptococcus pneumoniae TIGR4

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	mucosal immunization with ClpP antigen induces both systemic and mucosal antibodies, and in this way reduces lung colonization in an invasive pneumococcal pneumonia model and also protects mice against death in an intraperitoneal-sepsis model. Intraperitoneal immunization of BALB/c mice with recombinant ClpP protein. ClpP protein is immunogenic in healthy children and is expressed during disease based on the elevated antibody levels in infected individuals. In vitro functional anti-ClpP antibody can kill streptococcus pneumoniae by polymorphonuclear leukocytes in a complement-dependent assay	Streptococcus pneumoniae TIGR4	?	-	?

Synonyms

Synonyms	Comment	Organism
Caseinolytic protease	-	Streptococcus pneumoniae TIGR4
ClpP	-	Streptococcus pneumoniae TIGR4

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Release 2023.1 (January 2023)