Application | Comment | Organism |
---|---|---|
drug development | synthetic beta-lactones as novel inhibitors for specific and selective targeting of the key virulence regulator ClpP | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(4-methoxyphenyl)-4-(pent-4-ynyl)oxetan-2-one | shows stronger inhibitory effect | Staphylococcus aureus | |
3-(non-8-ynyl)-4-(pent-4-ynyl)oxetan-2-one | exerts the weakest effect on peptidase activity | Staphylococcus aureus | |
3-butyl-4-(pent-4-ynyl)oxetan-2-one | shows stronger inhibitory effect | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
ClpP | - |
Staphylococcus aureus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
3-(4-methoxyphenyl)-4-(pent-4-ynyl)oxetan-2-one | - |
Staphylococcus aureus | |
0.006 | - |
3-butyl-4-(pent-4-ynyl)oxetan-2-one | - |
Staphylococcus aureus | |
0.031 | - |
3-(non-8-ynyl)-4-(pent-4-ynyl)oxetan-2-one | - |
Staphylococcus aureus |