Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.92 extracted from

  • Woo, K.M.; Chung, W.J.; Ha, D.B.; Goldberg, A.L.; Chung, C.H.
    Protease Ti from Escherichia coli requires ATP hydrolysis for protein breakdown but not for hydrolysis of small peptides (1989), J. Biol. Chem., 264, 2088-2091.
    View publication on PubMed
Search for more literature for 3.4.21.92

Inhibitors

Inhibitors Comment Organism Structure
diisopropyl fluorophosphate blocks similarly the hydrolysis of both protein and peptide substrates Escherichia coli
NEM inactivates ATPase, no inhibition of peptide hydrolysis Escherichia coli
Succinyl-Leu-Tyr 4-methylcoumarin 7-amide at high concentrations complete inhibition of casein breakdown Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3
-
 N-Succinyl-Leu-Tyr 4-methylcoumarin 7-amide
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 RGC125 (lon-)
-
Escherichia coli RGC125 (lon-)
-
 RGC125 (lon-)
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Leu-Tyr 4-methylcoumarin 7-amide + H2O
-
 Escherichia coli N-succinyl-Leu-Tyr + 7-amino-4-methylcoumarin
-
 ?
N-succinyl-Leu-Tyr 4-methylcoumarin 7-amide + H2O
-
 Escherichia coli RGC125 (lon-) N-succinyl-Leu-Tyr + 7-amino-4-methylcoumarin
-
 ?
Succinyl-Ala-Ala-Phe 4-methylcoumarin 7-amide + H2O ClpP subunit alone Escherichia coli Succinyl-Ala-Ala + Phe 4-methylcoumarin 7-amide
-
 ?
Succinyl-Ala-Ala-Phe 4-methylcoumarin 7-amide + H2O ClpP subunit alone Escherichia coli RGC125 (lon-) Succinyl-Ala-Ala + Phe 4-methylcoumarin 7-amide
-
 ?
Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O ClpP subunit alone Escherichia coli Succinyl-Leu + Leu + Val-Tyr 4-methylcoumarin 7-amide
-
 ?
Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O ClpP subunit alone Escherichia coli RGC125 (lon-) Succinyl-Leu + Leu + Val-Tyr 4-methylcoumarin 7-amide
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP ATP hydrolysis is required for protein breakdown but not for hydrolysis of small peptides Escherichia coli